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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Clin Genet. 2016 Oct 6;91(4):589–598. doi: 10.1111/cge.12856

Fig. 1. Selected Pedigrees and Pure tone audiograms.

Fig. 1

Pedigree drawings are provided for four of the participating families with the Pure tone audiograms showing degree of hearing loss across the test frequency range. Hearing thresholds of unaffected age matched controls acquired in similar settings range between 20 dB HL and 30 dB HL. The ages of all affected individuals are noted on the right side of the audiogram. Results are plotted for the better hearing ear in each case. (a) Variable degree of mild-to-moderate, moderate-to-severe or moderate-to-profound hearing loss in family HLGM24 due to CDH23 missense mutation (b) Moderate, moderate-to-severe or moderate-to-profound hearing loss in family HLAI-16 due to MYO6 frameshift mutation (c) Mild-to-moderate, moderate, and moderate-to-severe hearing loss as observed in family HLGM19 which had a frameshift variant in TECTA. Note that one of the affected individuals has a significantly lesser degree of hearing loss (d) Moderate-to-severe or severe-to-profound hearing loss was present in family HLAI-22. The parents reported that the affected individuals had a progressive hearing loss.