Table 3.

Percentage contribution of genes to moderate or severe hearing loss in Pakistan

Gene/Locus	Number of familiesa	Percentage	95 % CI
SLC26A4	13	14.3	7.1-21.5
GJB2	9	9.9	3.8-16
MYO15A	7	7.7	2.2-13.2
TMC1	6	6.6	1.5-11.7
TMPRSS3	4	4.4	0.1-8.7
OTOF	4	4.4	0.1-8.6
MYO7A	3	3.3	0-7
CLDN14	3	3.3	0-7
Other 13 genes or loci	14	-	-
“New genes”b	2	-	-
Unknown	26	28.6	-
Total	91	-	-

CI, Confidence Interval.

^aPercentages are calculated on the basis of 91 pedigrees without the data of an USH1C family and includes data for families for which linkage was detected to a locus with a LOD score of ≥3 and a pathogenic mutation was not identified after sequencing the corresponding gene (MYO7A for HLAI-07, MYO15A for HLAI-08, SLC26A4 for HLMI01, TMC1 for HLAI-17, OTOF for HLGM06 and GPSM2 for HLRB11).

^bGRXCR2 and MET.