Table 2.

Genetic variants that affect GCT incidence in the 129/Sv mouse

Gene	Type of Variant	Increase vs Decrease incidence	Function (in wild-type)	References
Ago2Gt(XE344)Byg/Mmucd	Engineered Knockout	Increase	Biogenesis of non-coding RNAs	Carouge et al. 2016
Apobec1tm1Ddsn	Engineered Knockout	Increase	Cytidine deaminase	Nelson et al. 2012
Chr19MOLF/Ei (Sf1Gt(XD130)Byg and unknown genes)	Chromosome substitution (Genetrap)	Increase	Sf1, pre-mRNA splicing	Matin et al. 1999 Zhu et al. 2010
Dmrt1tm1.1Zark	Engineered Knockout	Increase	Transcription factor	Krentz et al., 2013
Dnd1Ter	Spontaneous Point Mutation	Increase	RNA-binding protein	Noguchi and Stevens 1982 Youngren et al. 2005
KitSl, KitSl-J, KitSl-gb	Spontaneous Deletions	Increase	Ligand for KIT receptor	Stevens 1967 Heaney et al. 2008
Nanos3tm2.1(cre)Ysa	Cre Knockin	Increase	RNA binding protein	Schemmer et al. 2013
Ptentm1Ppp & Ptentm2Mak floxed	Engineered Knockouts	Increase	Lipid phosphatase	Di Cristofano et al 1998 Kimura et al. 2003
Tfap2ctm1Hsc	Engineered Knockout	Increase	Transcription factor	Schemmer et al. 2013
Trp53tm1Brd	Engineered Knockout	Increase	Tumor suppressor	Harvey et al. 1993
Ay (Eif2s2Gt(XH413)Byg)	Spontaneous Deletion (Genetrap)	Decrease	Translation initiation	Stevens 1967 Heaney et al. 2009
A1cftm1Ddsn	Engineered Knockout	Decrease	RNA binding co-factor of APOBEC1	Carouge et al. 2016
Ccnd1tm1Wbg	Engineered Knockout	Decrease	Cell cycle, oncogene	Lanza et al. 2016