Fig. 2.

Concentrations of cefadroxil in the plasma (total drug, C_p,240), brain extracellular fluid (unbound drug, C_u,ECF or C_{u,ECF,220-240}) and cerebrospinal fluid (C_csf), as well as amount of cefadroxil in the brain parenchyma (A_brain) and brain cells (A_cell) of wildtype and Pept2 null mice at the end of the 4-hr intravenous infusion of 0.15 mg/min/kg cefadroxil. Data are expressed as mean ± SEM (n=6–12). *p<0.05 and **p<0.001 when comparing a parameter between two genotypes, as indicated by Welch’s t-test (for unequal variance) and by student’s t-test (for equal variance).