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Unbound volume of distribution (Vu,brain) of cefadroxil in different brain regions (A) and whole brain (averaged from the five regions) (B) of wildtype and Pept2 null mice at the end of a 4-hr intravenous infusion of 0.15 mg/min/kg cefadroxil. Data are expressed as mean ± SEM (n=11–12). Two-way ANOVA indicated that genotype and not brain region was an influencing factor for Vu,brain. Welch’s t-test indicated a significant differences in Vu,brain between the two genotypes.
