FIG 1.

HFIM total bacterial population counts in log₁₀ CFU/ml over 240 h following exposure to polymyxin B loading dose (2.22 mg/kg for 1 dose followed by 1.43 mg/kg q12h starting 12 h later), polymyxin B burst (5.53 mg/kg × 1 dose followed by no subsequent doses), meropenem (2 g q8h), and rifampin (600 mg q24h). Experiments were conducted at a starting inoculum of ∼10⁸ CFU/ml for KPC-Kp 9A versus monotherapies (A), KPC-Kp 9A versus combination therapies (B), and KPC-Kp 27A versus combination therapy (C).