TABLE 2.
Interactions of amphotericin B-rifampin combinations against ocular Fusarium solani species complex and Aspergillus flavus species complex isolates
| Combination | FICI and % of isolates showing interactiona |
|||||
|---|---|---|---|---|---|---|
|
Fusarium solani species complex (n = 51) |
Aspergillus flavus species complex (n = 44) |
|||||
| FICI (mean ± SD) | Synergy | Indifference | FICI (mean ± SD) | Synergy | Indifference | |
| AMB-RIF(4)b | 0.58 ± 0.24 | 11.8 | 88.2 | 0.61 ± 0.27 | 13.6 | 86.4 |
| AMB-RIF(8)c | 0.38 ± 0.19 | 51.0 | 49.0 | 0.42 ± 0.21 | 45.5 | 54.5 |
| AMB-RIF(16)d | 0.23 ± 0.19 | 90.2 | 9.8 | 0.19 ± 0.20 | 93.2 | 6.8 |
| AMB-RIF(32)e | 0.19 ± 0.11 | 94.1 | 5.9 | 0.17 ± 0.20 | 95.5 | 4.5 |
a
Interactions: synergy, FICI of ≤0.5; indifference, FICI of >0.5 and ≤4; antagonism, FICI of >4.
b
Amphotericin B at 10 concentrations in combination with 4 μg/ml rifampin.
c
Amphotericin B at 10 concentrations in combination with 8 μg/ml rifampin.
d
Amphotericin B at 10 concentrations in combination with 16 μg/ml rifampin.
e
Amphotericin B at 10 concentrations in combination with 32 μg/ml rifampin.