TABLE 3.

Pharmacokinetic parameters of benznidazole by sex after a single oral dose of 100 mg of benznidazole in the healthy volunteers (n = 8)

Parameter	Value ina:		P value
	Men (n = 4)	Women (n = 4)
BMIb (kg/m2)	25.4	22	0.34
Cmax (μg/ml)*	1.6 (1.4–1.9)	2.9 (2.6–3.1)	0.02
tmax (h) (range)	4.0 (2.5–5.5)	3.0 (2.3–3.8)	0.42
AUC0–t (μg · h/ml)	42.5 (33.2–48.3)	57.5 (40.3–60.7)	0.2
AUC0–∞ (μg · h/ml)	43.7 (34.2–50.4)	58.4 (40.5–61.9)	0.2
t1/2 (h)	13.9 (11.4–15.1)	11.3 (8.9–12.5)	0.2
V/F (liters)*	125.9 (109.1–193.9)	88.6 (82.2–96.6)	0.02
CL/F (liters/h)	6.9 (5.9–8.9)	5.1 (4.8–7.7)	0.2

^aData are reported as medians and interquartile ranges unless otherwise noted. *, P < 0.05 between men and women.

^bBMI, body mass index.