FIG 4.

PPMOs decreased P. aeruginosa burden in the lungs of infected mice. BALB/c mice were infected intratracheal with P. aeruginosaPA103 and treated with PPMOs or PBS control at 6 h postinfection. (a) The CFU/g of whole lung were analyzed. Statistics were determined with a one-way ANOVA and a Holm-Ŝidák's multiple-comparison test where P < 0.001 (**) compared to PBS and Scr-1073 controls and P < 0.001 (*) compared to PBS control. (b) H&E stains of the left distal lungs of infected mice treated as indicated compared to a naive control. The magnification in the top row is at ×4, with black boxes to indicate the regions pictured at ×40 magnification below. These data are combined from three independent experiments, except for RpsJ-0066, which was one experiment.