Bacteriostatic activity of TAC analogues against M. abscessus. (A to D) Concentration- and time-dependent activity of the three effective TAC analogues, as well as imipenem, was monitored. The number of CFU was determined after 0, 24, 48, 72, and 96 h of incubation with different concentrations of each drug. Values are means from two independent experiments. IPM, imipenem.