TABLE 5.
MICs of D6, D15, D17, and amikacin against MmpS5/MmpL5-overexpressing strains
| Straina | MIC (μg/ml) forb: |
|||
|---|---|---|---|---|
| D6 | D15 | D17 | AMK | |
| CIP104536 S | ||||
| Wild type | 25 | 12.5 | 12.5 | 25 |
| pMV261_mmpS5/mmpL5 | >200 | >200 | >200 | 25 |
| CIP104536 R | ||||
| Wild type | 12.5 | 3.1 | 6.25 | 25 |
| pMV261_mmpS5/mmpL5 | >200 | >200 | >200 | 12.5 |
a
M. abscessus S and R strains were transformed with pMV261_mmpS5/mmpL5.
b
The MICs were determined in cation-adjusted Mueller-Hinton broth. Data are representative of two independent experiments. AMK, amikacin.