TABLE 2.

ED₅₀ values for liposomal BPQ in L. infantum-infected hamsters^a

Treatment group (mg/kg/day)	Mean % infection ± SD		Mean ED50 (mg/kg) ± SD
	Spleen	Liver
0.6	2.46 ± 1.45	6.70 ± 5.51
0.3	56.43 ± 20.43	46.70 ± 36.28
0.1	94.72 ± 31.59	66.36 ± 38.88
Control (untreated)	100.00 ± 43.40	100.00 ± 40.15
ED50	0.31	0.19	0.25 ± 0.06

^aTreatment was performed using different doses administered s.c. for 10 consecutive days. The parasite load was evaluated using reverse transcription-quantitative PCR in the liver and spleen. ED₅₀, 50% effective dose.