TABLE 2.
Treatment group (mg/kg/day) | Mean % infection ± SD |
Mean ED50 (mg/kg) ± SD | |
---|---|---|---|
Spleen | Liver | ||
0.6 | 2.46 ± 1.45 | 6.70 ± 5.51 | |
0.3 | 56.43 ± 20.43 | 46.70 ± 36.28 | |
0.1 | 94.72 ± 31.59 | 66.36 ± 38.88 | |
Control (untreated) | 100.00 ± 43.40 | 100.00 ± 40.15 | |
ED50 | 0.31 | 0.19 | 0.25 ± 0.06 |
Treatment was performed using different doses administered s.c. for 10 consecutive days. The parasite load was evaluated using reverse transcription-quantitative PCR in the liver and spleen. ED50, 50% effective dose.