TABLE 1.
Plasma biochemical analysis of female mice after 48 h of VFV administration
| Enzyme | Mean level ± SDa after treatment with VFV at (mg/kg): |
|||||
|---|---|---|---|---|---|---|
| 0b | 12.5 | 25 | 50 | 100 | 200 | |
| ALT | 106 ± 39 | 72 ± 21 | 73 ± 13 | 62 ± 0 | 83 ± 38 | 161 ± 118 |
| CK | 396 ± 32 | 1,000 ± 30 | 446 ± 102 | 540 ± 255 | 369 ± 228 | 407 ± 336 |
| AST | 123 ± 6.4 | 168 ± 14 | 115 ± 16 | 92 ± 0 | 104 ± 40 | 70 ± 0 |
a
Values of two independent assays are shown. Reference values (CECAL/Fiocruz): ALT, up to 132 U/liter; AST, up to 247 U/liter; CK, up to 1,070 U/liter.
b
Results of one representative assay are shown.