FIG 1.

Time course of P. aeruginosa strains PAO1 (rows A and C) and the rhlR/lasR knockout strain (rows B and D) against polymyxin B (A1 to B3) or colistin (C1 to D3) at three different initial inocula: 10⁶ CFU_{0 h} (column 1), 10⁸ CFU_{0 h} (column 2), and 10⁹ CFU_{0 h} (column 3). Polymyxin B and colistin concentrations range from 0 to 128 mg/liter. Individual points represent observed viable colony counts (CFU/ml) from time-kill experiments, whereas lines represent expected bacterial killing as predicted by the previously validated mechanism-based model.