TABLE 1.

Anti-CHIKV effect of nucleoside analogs

Compound	EC50 (μM)c
	Huh-7–CHIKV replicon	BHK-21–CHIKV replicon	CHIKV infectious model (Asiana)	CHIKV infectious model (ECSAb)
NHC	0.8 ± 0.1	1.8 ± 0.2	0.2	0.2 ± 0.1
Favipiravir	12.7 ± 1.6	22.5 ± 4.7	0.3	0.6
Ribavirin	16.8 ± 2.2	7.8 ± 2.2	ND	ND

^aAsian strain CNR20235.

^bECSA strain LR 2006 OPY1.

^cCell-based EC₅₀s are the averages from two to four replicates ± standard deviations. ND, not determined.