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The pathway of tenofovir (TFV) transport in proximal tubular epithelium cells (1, 4, 5). Approximately, 20 to 30% of tenofovir is actively transported into renal proximal tubular cells by the organic anion transporters hOAT1 and, to lesser extent, hOAT3 (1, 4) at the basolateral membrane. Subsequently, the drug is secreted by ABCC4 (MRP4), ABCC10 (MRP7) (1, 4, 5), and ABCC11 (MRP8) (this study).
