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Intracellular accumulation of tenofovir (A) and methotrexate (B) with and without the specific MRP8-inhibitor MK-571 in a cellular transport assay. Error bars represent standard errors from duplicate independent experiments. Statistical significance was assessed by a two-way ANOVA multiple comparison test assuming equal variance. *, P < 0.01; **, P < 0.001; ***, P < 0.0001.
