TABLE 2.
Characteristics of patients positive for CR-ESBL strains compared to those of patients positive for carbapenem-susceptible ESBL-producing isolatesa
| Patient characteristic | Values for patients infected with: |
P valueb | |
|---|---|---|---|
| CR-ESBL strain (n = 90) | Carbapenem-susceptible ESBL-producing strain (n = 714) | ||
| Mean (SD) age (yr) | 56.9 (14.8) | 57.1 (16.3) | 0.89 |
| No. (%) of patients of male sex | 54 (60) | 395 (55.3) | 0.40 |
| No. (%) of patients of white race | 43 (48) | 338 (47.3) | 0.90 |
| Median (IQR) ICU length of stay (days) | 8.9 (17.0) | 5.4 (9.3) | 0.002c |
| Median (IQR) Charlson comorbidity index | 2.0 (2.0) | 2.0 (2.0) | 0.61c |
| No. (%) of patients receiving the following antibiotic before ICU stay: | 56 (62) | 350 (49) | 0.02 |
| Antipseudomonal | 44 (49) | 274 (38) | 0.05 |
| Anti-anerobic organism agent | 41 (46) | 267 (37) | 0.13 |
| Beta-lactam | 44 (49) | 294 (41) | 0.16 |
| Anti-MRSA agent | 39 (43) | 196 (28) | 0.002 |
| Vancomycin | 33 (37) | 173 (24) | 0.01 |
| Antifungals | 11 (12) | 51 (7.1) | 0.09 |
| Imipenem | 11 (12) | 43 (6.0) | 0.03 |
| Carbapenem | 16 (18) | 48 (6.7) | <0.001 |
| Any cephalosporin | 23 (26) | 117 (16) | 0.03 |
| 1st generation | 3 (3.3) | 48 (6.7) | 0.22 |
| 2nd generation | 5 (5.6) | 9 (1.3) | 0.01d |
| 3rd generation | 6 (6.7) | 30 (4.2) | 0.28d |
| Fluoroquinolones | 5 (5.6) | 68 (9.5) | 0.22 |
| Piperacillin-tazobactam | 26 (29) | 188 (26) | 0.60 |
| No. (%) of patients with the following comorbid illness: | |||
| HIV/AIDS | 4 (4.4) | 33 (4.6) | >0.99d |
| Cancer | 10 (11) | 85 (12) | 0.83 |
| Cerebrovascular disease | 7 (7.8) | 54 (7.6) | 0.94 |
| Chronic pulmonary disease | 14 (16) | 150 (21) | 0.23 |
| Heart failure | 19 (21) | 134 (19) | 0.59 |
| Dementia | 1 (1.1) | 2 (0.3) | 0.30d |
| Diabetes | 12 (13) | 136 (19) | 0.19 |
| Liver disease (severe) | 8 (8.9) | 45 (6.3) | 0.35 |
| Myocardial infarction | 7 (7.8) | 39 (5.5) | 0.37 |
| Peripheral vascular disease | 5 (5.6) | 30 (4.2) | 0.58d |
| Renal disease | 21 (23) | 145 (20) | 0.50 |
| Mean (SD) chronic disease score | 8.4 (4.0) | 8.1 (4.2) | 0.56 |
| No. (%) of patient deaths during admission | 24 (27) | 184 (26) | 0.85 |
a
Data are for 804 patients.
b
P values were from a chi-square test for categorical variables or Student's t test for continuous variables, except where noted.
c
Wilcoxon rank sum test.
d
Fisher's exact test.