TABLE 5.
Pharmacokinetic parameters of BNZ in mouse plasma after single oral dose of 100 mg/kg (n = 5)
| Pharmacokinetic parametera | Value (mean ± SD) |
|---|---|
| kel (h−1) | 0.34 ± 0.03 |
| t1/2b (h) | 2.03 ± 0.16 |
| ka (h−1) | 2.23 ± 0.41 |
| t1/2a (h) | 0.29 ± 0.03 |
| AUC0–6 (μg/ml · h) | 154.53 ± 1.57 |
| AUC0–∞ (μg/ml · h) | 195.71 ± 6.04 |
| MRT (h) | 3.86 ± 0.23 |
| Tmax (h) | 0.83 ± 0.29 |
| Cmax (μg/ml) | 41.61 ± 2.99 |
| V/F (ml) | 38.81 ± 2.02 |
| CL/F (ml/h) | 13.29 ± 0.41 |
a
kel, elimination constant; t1/2b, elimination half-life; ka, absorption constant; t1/2a, absorption half-life; AUC0–6, area under the concentration-time curve from 0 to 6 h; AUC0–∞, area under the concentration-time curve extrapolated to infinity; MRT, mean residence time; Tmax, time to achieve Cmax; Cmax, maximum concentration; V, volume of distribution; CL, clearance; F, bioavailability.