TABLE 6.

BNZ pharmacokinetic parameters in plasma and tissue biodistribution in mice after single oral dose of 100 mg/kg (n = 5)^a

Sample	AUC0–6 (μg/ml · h or μg/g · h)	R (%)	AUC0–∞ (μg/g · h)	MRT (h)	Tmax (h)	Cmax (μg/ml or μg/g)
Plasma	154.53 ± 1.57	100	195.71 ± 6.04	3.86 ± 0.23	0.83 ± 0.29	41.61 ± 2.99
Spleen	42.39 ± 3.41	27.4	44.11 ± 3.54	1.79 ± 0.11	0.58 ± 0.14	27.73 ± 2.14
Brain	28.76 ± 4.32	18.6	29.45 ± 4.23	2.01 ± 0.24	0.75 ± 0.25	12.39 ± 1.70
Colon	45.64 ± 6.73	29.5	46.09 ± 6.71	2.03 ± 0.22	0.67 ± 0.29	18.11 ± 1.32
Heart	49.42 ± 7.07	31.9	57.78 ± 10.24	2.42 ± 0.58	0.67 ± 0.29	21.68 ± 2.70
Liver	2.24 ± 0.16	1.4	2.86 ± 0.04	3.41 ± 0.17	0.75 ± 0.00	1.76 ± 0.19
Lung	96.06 ± 3.34	62.2	106.14 ± 5.34	2.74 ± 0.17	0.63 ± 0.13	34.58 ± 2.87
Kidney	11.75 ± 0.75	7.6	12.20 ± 0.74	2.00 ± 0.03	0.49 ± 0.02	6.98 ± 0.51

^aValues are means ± SDs. R, AUC_{0–6, tissue} /AUC_{0–6, plasma}.