TABLE 3.
Comparison of empirical Bayesian estimates for the final model using total body weight to correct for body size
| Parameter | Median (range) for age categorya |
|||||
|---|---|---|---|---|---|---|
| >2–6 yrsb |
>6–12 yrs |
>12 yrsc |
||||
| Nonobese (n = 8) | Obese (n = 12) | Nonobese (n = 15) | Obese (n = 20) | Nonobese (n = 26) | Obese (n = 44) | |
| CL (liters/h) | 4.17 (0.90–9.10) | 5.69 (1.84–8.27) | 12.50 (3.55–34.40) | 10.70 (4.71–26.70) | 14.25 (5.56–37.40) | 19.15 (3.92–33.70) |
| CL (liters/h/kg) | 0.23 (0.082–0.78) | 0.28 (0.11–0.40) | 0.33 (0.13–0.78) | 0.22 (0.092–0.64) | 0.23 (0.064–0.53) | 0.18 (0.041–0.65) |
| CL (liters/h/70 kg) | 10.64 (3.59–35.03) | 14.83 (5.49–20.32) | 20.67 (7.08–48.48) | 14.69 (5.94–39.16) | 15.82 (4.72–34.68) | 13.97 (3.12–37.89) |
| V (liters) | 15.25 (7.58–19.70) | 17.60 (8.39–25.20) | 29.0 (17.50–57.40) | 46.90 (32.90–85.80)** | 60.10 (22.50–94.60) | 85.75 (28.50–160.0)** |
| V (liters/kg) | 0.81 (0.69–1.26) | 0.86 (0.66–1.03) | 0.90 (0.67–1.06) | 1.03 (0.66–1.29) | 0.89 (0.70–1.34) | 0.89 (0.62–1.58) |
| Half-life (h) | 2.41 (1.12–5.85) | 2.15 (1.53–4.36) | 2.15 (0.95–5.77) | 3.03 (1.19–6.26)** | 2.84 (1.17–7.60) | 3.55 (0.90–11.30) |
a
Statistically significant differences (**) were observed using a rank sum test.
b
Three participants with missing height (and BMI) were not included in this parameter summary.
c
Ten participants (6 nonobese and 4 obese) who were >18 years of age were included in the parameter summary.