TABLE 2.
Log10 CFU per thigh counts for various antibiotic–β-lactamase inhibitor combinations in the neutropenic thigh infection model for K. pneumoniae 1.41-infected micea
| Treatment | Dose (mg/kg s.c. q8h, 5 mice/treatment) | Mean log10 CFU/thigh ± SD | Change from control at 24 h with no antibiotics (log10 CFU) | Tukey adjusted P value (treatment vs 24-h control) |
|---|---|---|---|---|
| 24-h infection control | NA | 8.46 ± 1.15 | NA | NA |
| CAZ | 256 | 5.37 ± 1.17 | −3.08 | 0.0405 |
| 128 | 6.12 ± 1.34 | −2.34 | 0.3152 | |
| 64 | 6.35 ± 1.57 | −2.11 | 0.4909 | |
| ATM | 256 | 7.30 ± 1.47 | −1.16 | 0.9912 |
| 128 | 6.46 ± 1.80 | −1.99 | 0.5873 | |
| 64 | 6.59 ± 2.02 | −1.86 | 0.6936 | |
| CAZ-AVI | 256/64 | 3.77 ± 0.18 | −4.68 | <0.0001 |
| 128/32 | 4.75 ± 1.00 | −3.70 | 0.0042 | |
| 64/16 | 6.23 ± 1.93 | −2.22 | 0.4018 | |
| 32/8 | 8.30 ± 0.88 | −0.16 | >0.9999 | |
| CAZ-AVI-ATM | 32/8/32 | 4.51 ± 0.42 | −3.95 | 0.0016 |
| 16/4/16 | 6.88 ± 1.63 | −1.58 | 0.8818 | |
| 8/2/8 | 6.57 ± 1.77 | −1.88 | 0.6777 | |
| 4/1/4 | 8.47 ± 0.85 | 0.02 | >0.9999 |
a
Infection was 5 log10 CFU/mouse with 5 mice per treatment group. Boldface indicates a statistically significant value. NA, not applicable.