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. 2017 Feb 1;105(4):970–979. doi: 10.3945/ajcn.116.144550

FIGURE 1.

FIGURE 1

Joint effects of CaD supplementation and genetic risk score on total fracture risk, median follow-up 6.5 y, for Fx-GRS (A) and BMD-GRS (B). Fx-GRS, Q1: <13.0, Q2–3: 13.0 to <16.4, and Q4: ≥16.4. BMD-GRS, Q1: <47.5, Q2–3: 47.5 to <53.9, and Q4: ≥53.9. Cox regression models were adjusted for age (years) and Women’s Health Initiative genome-wide association study (GARNET or WHIMS+). Case-only analysis models were adjusted for age (years) and Women’s Health Initiative genome-wide association study (GARNET or WHIMS+). BMD-GRS, bone mineral density genetic risk score; CaD, calcium with vitamin D; Fx-GRS, fracture genetic risk score; GARNET, Genomics and Randomized Trials Network; GRS, genetic risk score; Q, quartile; RERI, relative excess risk due to interaction; WHIMS+, Women’s Health Initiative Memory Study +.