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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Nature. 2017 Mar 8;543(7646):519–524. doi: 10.1038/nature21411

Extended Data Figure 1. Limitations of current genome-wide methods for measuring chromatin interactions.

Extended Data Figure 1

a, The table lists the current genome-wide methods for measuring chromatin interactions and compares their various limitations. CNVs = copy number variants. b, GAM has few of the limitations that affect current genome-wide methods for mapping genome architecture. c, In 3C-based methods, the presence of multiple loci in a single interaction may dilute the measured ligation frequency between any two member loci. In GAM, the measured interaction is not affected by multiplicity. d, Two interactions on different chromosomes (or distant on the same chromosome) can be correlated (occur together in the same cells), anti-correlated (one interaction occurs whilst the other does not) or independent (they occur either together or in different single cells randomly).