Table 3.
Foci of significant activation for rumination versus distraction between groups.
| Contrast/lobe | BA | MNI coordinates
|
Z | k | p- value | Factor | DMN | ||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| rMDD > HC | |||||||||
| Frontal | |||||||||
| Precentral | 44 | 56 | 6 | 10 | 3.88 | 544 | <.001 | 1 | Out |
| Precentral | 4 | −40 | −10 | 44 | 3.73 | 1007 | <.001 | 1 | Out |
| Dorsal Cingulate | 24 | −2 | 4 | 44 | 3.85 | 1079 | <.001 | 1 | Out |
| Temporal | |||||||||
| Fusiform | 19 | −40 | −50 | −14 | 4.73 | 996 | <.001 | 2 | Out |
| Middle | 30 | −32 | −72 | 14 | 3.46 | 76 | <.001 | 1 | In |
| Temporal | |||||||||
| Superior | 22 | 64 | −14 | 6 | 3.36 | 82 | <.001 | 2 | In |
| Parietal | |||||||||
| Inferior | 40 | 66 | −34 | 34 | 3.71 | 474 | <.001 | 2 | In |
| Precuneus | 7 | −4 | −42 | 56 | 3.99 | 1279 | <.001 | 2 | In |
| Precuneus | 31 | 24 | −68 | 30 | 3.49 | 715 | <.001 | 2 | In |
| Subcortical | |||||||||
| Insula | 13 | 40 | −22 | −2 | 3.82 | 279 | <.001 | 1 | Out |
| Thalamus/Putamen/Amygdala/PHG/SGACC | - | 12 | −12 | 0 | 3.91 | 2093 | <.001 | 2 | In/Out |
| Occipital | |||||||||
| Inferior | 19 | 46 | −72 | 4 | 3.88 | 212 | <.001 | 1 | Out |
| Lingual | 19 | 32 | −58 | 4 | 4.00 | 600 | <.001 | 1 | Out |
| Lingual | 19 | −26 | −70 | 2 | 3.25 | 69 | <.005 | 2 | Out |
Note: BA = Brodmann Areas; DMN = Default Mode Network; MINI = Montreal Neurological Institute; PHG = Parahippocampal Gyrus. The last column denotes whether the significant region was inside or outside of the DMN mask.