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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Curr Genet. 2016 Sep 25;63(3):401–409. doi: 10.1007/s00294-016-0653-8

Table 1.

Comparisons of telomere recombination pathways

Pathway Activating
Factors
Repressing
Factors
Telomere structures
ALT BLM
MRE11
NBS1
RAD50
ATRX
DAXX1
ASF1
heterogeneous terminal tract
lengths

unpaired G and C-strand at
chromosome ends

ECTRs

C-circles, G-circles and t-circles
S. cerevisiae
type I survivor
Rad51
Rad52
Rad54
Rad55
Rad57
increased Y’ elements at
chromosome ends

short terminal TG1–3
S. cerevisiae
type II survivor
Mre11
Rad50
Rad52
Rad59
Xrs2
Sgs1
Tel1
Mec1
heterogeneous terminal tract
lengths

t-circles
S. pombe
linear survivor
Rad22
Rad32
Rad50
Nbs1
Rap1
Taz1
Trt1
Est1
Ku70
heterogeneous terminal tract
lengths
U. maydis ALT-like Blm
Mre11
Ku70
Ku80
heterogeneous terminal tract
lengths

unpaired C-strand at
chromosome ends

linear and circular ECTRs

t-circles, C-circles, and G-circles