Table 2.
Diagnostic value of urinary [TIMP-2] × [IGFBP7] for acute kidney injury in individual studies
| First author, year [reference] | Number of patients | Sensitivity (95% CI) | Specificity (95% CI) | AUC | Cutoff value | |||
|---|---|---|---|---|---|---|---|---|
| TP | FP | FN | TP | |||||
| Kashani, 2013 [8] | 90 | 313 | 11 | 314 | 0.89 (0.81–0.94) | 0.50 (0.46–0.54) | 0.80 | 0.3 |
| Bihorac, 2014 [21] | 65 | 182 | 6 | 155 | 0.92 (0.83–0.97) | 0.46 (0.41–0.51) | 0.82 | 0.3 |
| Hoste, 2014 [22] | 24 | 59 | 3 | 67 | 0.89 (0.71–0.98) | 0.53 (0.44–0.62) | 0.79 | 0.3 |
| Meersch, 2014 [23] | 21 | 4 | 5 | 20 | 0.81 (0.61–0.93) | 0.83 (0.63–0.95) | 0.81 | 0.3 |
| Wetz, 2015 [24] | 8 | 1 | 8 | 25 | 0.50 (0.25–0.75) | 0.96 (0.80–1.00) | 0.71 | 1.07 |
| Pilarczyk, 2015 [25] | 5 | 10 | 1 | 44 | 0.89 (0.36–1.00) | 0.81 (0.69–0.91) | 0.82 | 0.89 |
| Gocze, 2015 [26] | 32 | 9 | 13 | 53 | 0.71 (0.56–0.84) | 0.85 (0.74–0.93) | 0.85 | 0.3 |
| Kimmel, 2016 [27] | 35 | 118 | 11 | 134 | 0.76 (0.61–0.87) | 0.53 (0.47–0.59) | 0.76 | 0.3 |
| Dusse, 2016 [28] | 8 | 3 | 0 | 29 | 1.00 (0.63–1.00) | 0.91 (0.75–0.98) | 0.97 | 1.03 |
Abbreviations: IGFBP7 Insulin-like growth factor-binding protein 7, TIMP-2 Tissue inhibitor of metalloproteinase-2; TP True-positive, FP False-positive, FN False-negative, TP True-negative