Table 2.
In vitro anti-plasmodial activity and cytotoxicity of plant extracts
| Plant (Family) | Part (extract) | Antiplasmodial activity | Cytotoxicity | Selectivity index (SI) |
|---|---|---|---|---|
| IC50 on Dd2 (μg/mL ± SD) |
CC50 on LLC-MK2 (μg/mL ± SD) | |||
| Erythrina schliebenii (Fabaceae) | R (80% Ethanol) | 1.87 ± 0.44 | >200 | >109 |
| SB (H2O) | 7.04 ± 0.72 | >200 | >28.4 | |
| Holarrhena pubescens (Apocynaceae) | R (80% Ethanol) | 2.43 ± 0.15 | >200 | >82.3 |
| R (Methanol) | 2.05 ± 0.56 | >200 | >97.6 | |
| Dissotis melleri Hook.f (Melastomataceae) | AP (80% Ethanol) | 8.23 ± 1.32 | 83.33 ± 3.31 | 10.1 |
| Caesalpinia bonducella (Caesalpinaceae) | R (Dichloromethane) | 24.05 | >200 | >8.3 |
| QN | 0.06 ± 0.01 | |||
| Gleevec® (Imatinib) | 19.43 ± 2.87 |
R root, SB stem bark, AP aerial parts (stem + leaves), QN quinine