Table 1.

Main characteristics of enrolled studies.

First author	Time	Country	Age	Number of patients	Survival results	Test method	Tumor types	HR	Follow-up time	Cancer stage	Expression location	Cut-off value	NOS score
Li	2005	China	24–69	51	DFS	IHC	HCC	Univariate	5–90 months	NA	Cell surface	Positive: more than 10% of cells stained	7
Zhang∗	2006	China	48.52 ± 9.60	82	RFS	IHC	HCC	Multivariate	1–45 months	TNMI-χ	Cell surface	Positive: more than 10% of cells stained	7
Zhang	2007	China	24–66	111	RFS	IHC	HCC	Multivariate	1–63 months	TNMI-χ	Cell surface	NA	7
Wang	2012	China	28–65	272	OS, MST	IHC	HCC	Univariate	NA	TNMI-χ	Cell surface	Positive: scores# ≥ 2 were positive	7
Li	2010	China	15–65	83	OS, MST	IHC	HCC	Univariate	1–101 months	TNMI-χ	Cell surface	Positive: more than 10%	6
Luo∗	2011	China	NA	180	RFS	IHC	HCC	Univariate	0–12 months	TNMI-χ	Cell surface	Positive: more than 5%	6
Zhang	2014	China	24–66	51	OS, MST	IHC	HCC	Univariate	2–60 months	TNMI-χ	Cell surface	NA	6
Zhu	2015	China	31–76	50	OS	IHC	HCC	Multivariate	0–48 months	NA	Cell surface	Positive: more than 5%	7

MST: median survival time; ∗: the research is liver transplantation; scores^#: The positive cells were classified into 4 grades on the basis of the percentage of the positive cells: the number of the cells below 5% was zero score, 6%–25% was 1 score, 26%–50% was 2 score, and higher than 51% was 3 score; second the positive cells were classified into 4 grades on the basis of intensity of color: colorless was zero score, yellow was 1 score, light brown was 2 score, and deep brown was 3 score. Then the two kinds of scores were added: the score which was lower than 1 was negative and that which was higher than 2 was positive.