Table 3.
Results of subgroups analysis.
| OS | DFS/RFS | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number | HR (95% CI) | P h | I 2 (%) | P | Model | Number | HR (95% CI) | P h | I 2 (%) | P | Model | |
| Total | 4 | 4 | ||||||||||
| Univariate/Multivariate | ||||||||||||
| Multivariate | 1 | 0.5 (0.26, 0.96) | 0.04 | 2 | 7.72 (2,86, 20.86) | 0.84 | 0 | <0.0001 | Fixed | |||
| Univariate | 3 | 2.21 (1.44, 3.38) | 0.15 | 48 | 0.0003 | Fixed | 2 | 2.08 (1.01, 4.26) | 0.75 | 0 | 0.05 | Fixed |
| Follow-up time | ||||||||||||
| More than 5 years | 2 | 1.75 (0.57, 5.34) | 0.1 | 63 | 0.33 | Random | 2 | 2.10 (0.84, 5.23) | 0.46 | 0 | 0.11 | Fixed |
| Less than 5 years | 1 | 0.50 (0.26, 0.96) | 0.04 | 2 | 4.40 (2,07, 9.36) | 0.11 | 60 | 0.0001 | Fixed | |||
| Liver transplantation | ||||||||||||
| Yes | 0 | 2 | 4.40 (2.07, 9.36) | 0.11 | 60 | 0.0001 | Fixed | |||||
| No | 4 | 1.35 (0.56, 3.29) | 0.0006 | 83 | 0.51 | Random | 2 | 2.10 (0.84, 5.23) | 0.46 | 0 | 0.11 | Fixed |
| Cut-off value | ||||||||||||
| More than 10% of cells stained | 1 | 2.80 (1.41, 5.56) | 0.03 | 2 | 3.81 (0.92, 15.76) | 0.05 | 75 | 0.07 | Random | |||
| Less than 10% of cells stained | 1 | 0.50 (0.26, 0.96) | 0.04 | 2 | 2.64 (0.96, 7.25) | 0.56 | 0 | 0.06 | Fixed | |||
P h means the heterogeneity of P value.