Table 5.
Effect of M. inermis in scopolamine-induced cognitive impairment mice in MWM.
| Doses | Escape latency (seconds) | Time spent in target quadrant (seconds) | |||
|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | ||
| H2O + Scop | 105 ± 7.5 | 90.4 ± 9.8 | 65.4 ± 7.4 | 48.2 ± 3.7b | 50.6 ± 2.9b |
| 39,3 + Scop | 108.8 ± 6.8 | 90.8 ± 10.6 | 65.6 ± 7.0 | 44.6 ± 3.4 | 53.0 ± 3.5 |
| 98,25 + Scop | 101.8 ± 10.8 | 95 ± 9.9 | 65.4 ± 6.9 | 41.0 ± 1.6∗∗ | 63.2 ± 2.6∗∗ |
| 196,5 + Scop | 104.6 ± 7.5 | 91.6 ± 7.7 | 53.2 ± 6.1 | 32.2 ± 1.9∗∗∗ | 68.4 ± 2.7∗∗∗ |
| 393 + Scop | 98 ± 5.8 | 86 ± 9.9 | 50 ± 7.3 | 39.8 ± 1.3∗∗∗ | 64.8 ± 3.8∗∗ |
| Pira + Scop | 105.4 ± 8.9 | 85.4 ± 7.4 | 53.8 ± 9.6 | 41.6 ± 2.7∗∗ | 66.0 ± 2.6∗∗∗ |
| H2O + H2O | 101 ± 7.8 | 86.2 ± 6.3 | 62.8 ± 7.7 | 41.2 ± 1.3∗∗ | 65.4 ± 3.2∗∗ |
Data are mean ± SD, n = 5 per dose. ∗∗P < 0.01, and ∗∗∗P < 0.001, compared to scopolamine treated group (H2O + Scop), one-way ANOVA followed by Dunnett's bilateral comparisons. bP < 0.01 compared to normal control group (H2O + H2O), one-way ANOVA followed by Dunnett's bilateral comparisons. H2O: distilled water, Pira: piracetam 200 mg/kg, Scop: scopolamine 1 mg/kg.