Table 2.

Partial correlations between neuroimaging biomarkers and the five CCs domain scores in MCI subjects from the ACE study (n = 20) and the AB255 study (n = 133)

CCs related to:	(A) aHV		(B) FDG-PET		(C) PIB-PET
	β	p-value	β	p-value	β	p-value
Learning CC	0.09	0.74	0.06	0.82	– 0.02	0.92
	0.13	0.12	0.05	0.59	NA	NA
Delayed Recall CC	– 0.02	0.94	0.06	0.82	– 0.61	0.003*
	0.27	0.01*	0.27	0.01*	NA	NA
Executive Functions CC	0.29	0.24	0.23	0.37	– 0.19	0.45
	0.01	0.92	0.21	0.03	NA	NA
Language CC	0.23	0.37	– 0.04	0.87	0.21	0.40
	0.06	0.51	0.04	0.65	NA	NA
Praxis CC	0.19	0.46	– 0.01	0.97	– 0.07	0.79
	– 0.08	0.33	0.13	0.14	NA	NA

Values in regular print correspond to ACE study and values in bold correspond to AB255 study; CC, Cognitive Composite domain score; aHV, adjusted hippocampal volume; β, partial correlations adjusted by age, gender, and education; NA, not applicable; ^*Statistically significant after Bonferroni’s correction p≤0.01.