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. 2017 Mar 27;8:316. doi: 10.3389/fimmu.2017.00316

Figure 2.

Figure 2

The innate CD8(+) T cells in humans. (A) Representative view of human innate CD8(+) T cells. The membrane markers KIR/NKG2A, CD56, CD57, CD45RA, and CD49d and nuclear transcription factors Eomes and T-bet define this new unique innate CD8(+) T-cell population [for details, see Ref. (4, 38)]. Innate CD8(+) T cells in humans have the capacity to respond to IL-12 + IL-18 innate-like stimulation. Their development and homeostasis are regulated by IL-15, IL-4 [presumably by PLZF(+) iNKT cells], and expectedly type I interferons. Note that the precise origin (central vs. peripheral) of innate CD8(+) T-cell populations in humans remains under debate. (B) Gating strategy for innate CD8(+) T cells among peripheral blood mononuclear cells from healthy donors. After gating on T-cell receptor (TCR)-αβ(+) CD8(+) cells, the innate CD8(+) T cells are defined as KIR/NKG2A(+) Eomes(+). Frequency of innate CD8(+) T cells is displayed in the upper right corner.