Table 1.
Functional interactions between membrane-associated progesterone receptors (MAPR) proteins and cytochrome P450 system.
| MAPR | CYP | System | Enzymatic activity | Direction of influence | Reference |
|---|---|---|---|---|---|
| IZA/PGRMC1 (rat) | CYP21A2 (rat) | Inhibition by anti-IZA monoclonal antibody | Progesterone 21-hydroxylase | Activation | Laird et al., 1988 |
| IZA/PGRMC1 (rat) | CYP21A2 (rat) | COS-7 cell coexpression | Progesterone 21-hydroxylase | Activation | Min et al., 2004 |
| IZA/PGRMC1 (rat) | CYP17 (guinea pig) | COS-7 cell coexpression | Progesterone 17α-hydroxylase | Little or no influence | Min et al., 2005 |
| IZA/PGRMC1 (rat) | CYP17 (guinea pig) | COS-7 cell coexpression | 17α-Hydroxyprogesterone 17–20 lyase | Activation | Min et al., 2005 |
| IZA/PGRMC1 (rat) | CYP11B1 (rat) | COS-7 cell coexpression | Progesterone 11β-hydroxylase | Little or no influence | Min et al., 2004 |
| PGRMC1 (human) | CYP19A1 (human) | CYP19-engineered MCF-7 human breast cancer cells RNAi knockdown | Androst-4-ene-3,17-dione conversion | Activation | Ahmed et al., 2012 |
| Dap1/PGRMC1 (S. cerevisiae) | CYP51A1 (S. cerevisiae) | S. cerevisiae genetics | Lanosterol-14-demethylase | Activation | Hand et al., 2003 Mallory et al., 2005 |
| Dap1/PGRMC1 (S. pombe) | CYP51A1 (S. pombe) | S. pombe strain lacking DAP1 | Lanosterol-14-demethylase | Activation | Hughes et al., 2007 |
| Dap1/PGRMC1 (S. pombe) | CYP61A1 (S. pombe) | S. pombe strain lacking DAP1 | Lanosterol-22-desaturase | Activation | Hughes et al., 2007 |
| PGRMC1 (rabbit) | CYP2C2 (rabbit) | HEK293, HepG2 cell coexpression | Luciferin 6′ methyl ether O-demethylation | Inhibition | Szczesna-Skorupa and Kemper, 2011 |
| PGRMC1 (human) | CYP2C8 (human) | HEK293, HepG2 cell coexpression | Luciferin 6′ methyl ether O-demethylation | Inhibition | Szczesna-Skorupa and Kemper, 2011 |
| PGRMC1 (human) | CYP3A4 (human) | HEK293, HepG2 cell coexpression | Luciferin 6′ pentafluorobenzyl ether depentafluorobenzylation | Inhibition | Szczesna-Skorupa and Kemper, 2011 |
| PGRMC1 (human) | CYP2C9 (human) | HepG2 coexpression, human hepatocytes RNAi knockdown | S-Warfarin 7-hydroxylase and diclofenac 4′-hydroxylase | Inhibition | Oda et al., 2011 |
| PGRMC1 (human) | CYP3A4 (human) | HepG2 coexpression, human hepatocytes RNAi knockdown | Testosterone 6β-hydroxylase and midazolam 1′-hydroxylase | Inhibition | Oda et al., 2011 |
| PGRMC1 (human) | CYP2E1 (human) | HepG2 coexpression, human hepatocytes RNAi knockdown | Chlorzoxazone 6-hydroxylase and 7-ethoxycoumarin O-deethylase | No influence | Oda et al., 2011 |
| PGRMC2 (human) | CYP3A4 (human) | Human liver genetic association | Atorvastatin 2-hydroxylase | Inhibition | Klein et al., 2012 |
| CYB5D2 (human) | CYP3A4 (human) | Hela cell expression and RNAi knockdown | Luciferin 6′ pentafluorobenzyl ether depentafluorobenzylation | Activation | Bruce and Rybak, 2014 |