Table 3.

Changes in the transcript level of relevant transporters and other genes when treated with gemcitabine and/or fragment D1.

Gene	Fold changes
	Treatment with 100 nM GEM	Treatment with MBF D1 only	Treatment with MBF D1 and 100 nM GEM
ENT1	0.87 ± 0.13	0.79 ± 0.12	1.08 ± 0.17
ENT2	0.57 ± 0.13	0.98 ± 0.27	0.59 ± 0.17
ENT3	2.58 ± 0.11	1.18 ± 0.64*	0.89 ± 0.20***
ABCC2	12.27 ± 0.34	0.66 ± 0.14***	1.33 ± 0.33***
ABCC3	0.16 ± 0.48	2.10 ± 0.09**	0.54 ± 0.18
ABCC4	0.53 ± 0.10	0.90 ± 0.23	0.36 ± 0.14
ABCC5	0.50 ± 0.11	1.18 ± 0.32*	1.21 ± 0.15**
ABCC10	1.61 ± 0.48	0.53 ± 0.08*	0.48 ± 0.16*
RRM1	4.43 ± 0.13	1.11 ± 0.17***	2.07 ± 0.16***

Only those transcripts detectable within 35 PCR cycles are shown. Data are given as mean ± standard deviation. A 2-sided T-test was performed to assess statistical significance against GEM alone, P-values being encoded as

^*< 0.05,

^**< 0.01,

^***< 0.001.