Table 4.
Changes in the transcript level of ABCC2 and RRM1 when treated with gemcitabine and/or the other fragment hits.
| Treatment | Gene fold changes | ||||
|---|---|---|---|---|---|
| ABCC2 | STDEV | RRM1 | STDEV | ||
| GEM | 100 nM GEM | 12.27 | ±0.34 | 4.43 | ±0.13 |
| MBF D1 | MBF D1 only | 0.66*** | ±0.14 | 1.11*** | ±0.17 |
| MBF D1 + 100 nM GEM | 1.33*** | ±0.33 | 2.07*** | ±0.16 | |
| MBF B1 | MBF B1 only | 0.49*** | ±0.08 | 1.22*** | ±0.12 |
| MBF B1 + 100 nM GEM | 1.21*** | ±0.53 | 2.77*** | ±0.11 | |
| MBF 10 | MBF 10 only | 1.00*** | ±0.23 | 1.76*** | ±0.14 |
| MBF 10 + 100 nM GEM | 0.68*** | ±0.05 | 1.56*** | ±0.08 | |
| MBF 11 | MBF 11 only | 1.09*** | ±0.09 | 1.04*** | ±0.11 |
| MBF 11 + 100 nM GEM | 0.93*** | ±0.15 | 1.88*** | ±0.20 | |
| MBF 12 | MBF 12 only | 0.65*** | ±0.13 | 1.39*** | ±0.09 |
| MBF 12 + 100 nM GEM | 1.25*** | ±0.19 | 2.11*** | ±0.15 | |
| MBF 20 | MBF 20 only | 0.7*** | ±0.06 | 1.43*** | ±0.11 |
| MBF 20 + 100 nM GEM | 1.13*** | ±0.05 | 2.02*** | ±0.12 | |
A 2-sided T-test was performed to assess statistical significance vs. GEM alone, P-values being encoded as * < 0.05, ** < 0.01,
***
< 0.001.