Table 2.
Effect of edaravone (1, 5, 10 mg/kg), DPI (4 mg/kg), and AG (100 mg/kg) treatment on histological changes of kidney tissue in CsA-treated rats
| Group | Tubular atrophy | Tubulointerstitial fibrosis | Vascular thickening | Chronic inflammatory cells Infiltration |
|---|---|---|---|---|
| Vehicle (olive oil) | - | - | - | - |
| CsA (15) | ++ | ++ | ++ | ++ |
| CsA+edaravone (1) | ++ | ++ | - | ++ |
| CsA+edaravone (5) | ++ | ++ | - | ++ |
| CsA+edaravone (10) | + | + | - | + |
| CsA+DPI (4) | ++ | ++ | - | ++ |
| CsA+AG (100) | ++ | ++ | - | ++ |
| CsA+edaravone (10)+DPI (4) | + | + | - | + |
| CsA+edaravone (10)+AG (100) | + | + | - | + |
None (-), mild (+), moderate (++), severe (+++). CsA: Cyclosporine A; DPI: Diphenyliodonium chloride; AG: Aminoguanidine