Skip to main content
. 2017 Mar 27;8:327. doi: 10.3389/fimmu.2017.00327

Figure 2.

Figure 2

Dendritic cell (DC) and T cell subsets in vertebrates. Following the addition of GMCSF and IL-4, monocytes undergo differentiation into immature dendritic cells (iDCs). The addition of various cytokines (adjacent to arrows) permits iDC differentiation into three different DC subsets that include mature dendritic cells, semi-mature dendritic cells, and regulatory dendritic cells (rDCs). Only rDCs and semi-mature dendritic cells express costimulatory factors CD86 and CD80 and secrete the cytokine IL-10 known to stimulate naïve Th0 cell differentiation into Th2 cells and Th3 or Tr1 regulatory T cells. In contrast, mDCs secrete pro-inflammatory cytokines IL-6 and IL-12 that stimulate naïve Th0 cell development into pro-inflammatory Th1 and Th17 lymphocytes.