Figure 1. Alpha diversity is affected by probiotic L. reuteri treatment and progression of C. rodentium infection.

(A) A timeline of the experimental design. Mice were exposed to SDR from 0 DPI to 5 DPI. All mice were infected w/C. rodentium immediately following the first cycle of SDR (0 DPI), and half of the mice were gavaged w/L. reuteri following all six cycles of SDR. The other half received a PBS vehicle gavage as control. Mice were harvested at 1, 6, 12, and 24 DPI. (B) There is an effect of DPI upon the Shannon Diversity Index. Post-hoc testing indicated that the alpha diversity of mice at 24 DPI were significantly increased over those at 12 DPI. (C) There is also an effect of L. reuteri treatment upon the Chao1 Richness Index over all DPI.