Figure 1. Effect of chromium picolinate in vivo on body weight, non-fasted blood glucose, plasma total cholesterol and total triglyceride levels in STZ-induced hyperglycemic ApoE^−/− mice.

Six weeks old male ApoE^−/− mice were treated with 50 mg/Kg/day streptozotocin or sodium citrate buffer (vehicle control) i.p. for 5 consecutive days. This was followed by treatment with or without CrP (8 μg/Kg/day) in drinking water beginning at 8 weeks of age. (a) Body weight and (b) non-fasted blood glucose levels were measured every two weeks from 8–18 weeks of age. (c) Plasma total cholesterol and (d) plasma total triglyceride levels were measured at end point of the study (18 weeks). Results are expressed are mean ± SD (n = 10–17 mice per group); *p ≤ 0.05 vs. Control.