Figure 4. Chromium picolinate in vivo prevents hyperglycemia-induced smooth muscle cell abundance and increased cellular proliferation in aortic root lesions of STZ-treated ApoE^−/− mice.

Shown are (a) representative images for PCNA and α-SMA co-staining (10x magnification). Regions used for immunostaining quantifications are outlined by dotted lines; arrows indicate PCNA-positive smooth muscle cells. (b,c) Summary data for quantification of α-SMA-and PCNA-positive staining. All results are presented as fold of Control and values are expressed as mean ± SD (Control: n = 6; STZ: n = 7; STZ+CrP: n = 6); ^*p < 0.0001 vs. Control, ^#p < 0.0001 vs. STZ.