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. 2017 Mar 27;7:45279. doi: 10.1038/srep45279

Figure 7. Deletion of TSP-1 prevents formation of atherosclerotic lesions in STZ-induced hyperglycemic ApoE−/− mice.

Figure 7

Age-matched male ApoE−/− and TSP-1−/−/ApoE−/− dKO mice were subjected to STZ-induced hyperglycemia; aortic root morphometry was performed as described in Methods. Shown are (a,b) representative ORO images and summary data for quantification of ORO positive staining (STZ-ApoE: n = 7; STZ-TSP-1/ApoE: n = 5); (c,d) representative H & E images and summary data for neointimal thickness (STZ-ApoE: n = 7; STZ-TSP-1/ApoE: n = 5); (e,f) representative images and summary data for quantification of MT positive staining (STZ-ApoE: n = 8; STZ-TSP-1/ApoE: n = 5). Specific regions used for analyses are indicated by dotted lines. Results are presented as fold of ApoE−/− Control; all values are expressed as mean ± SD; *p ≤ 0.0013 vs. STZ-ApoE−/−.