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. 2017 Mar 27;7:45275. doi: 10.1038/srep45275

Figure 6. LOX-1 promotes migration, invasion and EMT of gastric cancer cells through activating PI3K/Akt/GSK3β pathway.

Figure 6

(a) The western blot analysis was performed to detect the expression of Akt, GSK3β, phospho-Akt (Ser473 and Thr308) and phospho-GSK3β (Ser9) in LOX-1-overexpressing MGC80-3 cells and LOX-1-knock-down AGS cells. (b) MGC80-3 cells transfected with vector or LOX-1 were treated with or without LY294002, and the expression of ZO-1, E-cadherin, Vimentin, Snail and Twist were detected by western blotting. (c) MGC80-3 cells transfected with vector or LOX-1 were treated with or without LY294002 (LY), and applied to transwell analysis. Images shown were representative in each group. Data are mean ± SD.