Figure 1. Comparison of autosomal CNVs in the placental and parental samples of recurrent pregnancy loss (RPL) cases compared to controls representing normal 1^st trimester and term pregnancy.

(a) Parental genomes of RPL patients and controls show no significant difference in the number of CNVs. A significantly lower number of CNVs was detected in the placental genomes of RPL patients compared to normal pregnancies; placentas from RPL couples eventually succeeding in a term live birth after a successful pregnancy are indicated with green diamonds. P-values for the differences among the groups were calculated by Wilcoxon rank sum test. Error bars show median values with interquartile range. (b) Venn-diagrams illustrating the degree of overlap in CNVRs detected in the parental and placental genomes from RPL cases and controls. (c) Gene enrichment analysis of CNVRs exclusively detected in the placental genomes of 1^st trimester and term control pregnancies. TFBS, transcription factor binding site.