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. 2017 Mar 27;7:45385. doi: 10.1038/srep45385

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Copyright © 2017, The Author(s)

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Beclin1 progressively relocalizes to the nucleus during mammalian development, and its nuclear localization is particularly increased when under extreme stress. Beclin 1 plays a critical role in protecting the nucleus during development and alleviating extreme life-threatening levels of stress by promoting DNA DSB repair. The role of Beclin 1 in mitigating DNA damage depends on its interaction to DNA topoisomerase IIβ that recruits Beclin 1 to DNA damage site. Beclin 1 is indispensible for both the activation of DNA repair proteins and the formation of NR and DNA-PK repair protein complexes. The role of Beclin 1 in DNA damage repair is independent on autophagy-mediated pathway.