Fig. 4.

Effects of taxifolin and allopurinol on liver uric acid levels (a) and xanthine oxidase activity (b) in hyperuricemic mice. The mice were orally administered with taxifolin and allopurinol at the different doses indicated. The mice were then intraperitoneally injected with both GMP and IMP (300 mg each/kg body weight) to induce hyperuricemia. Normal control and model control groups were treated with vehicles instead of test samples and nucleotides. Each value represents mean ± SEM for eight mice (duplicate measurements per mouse). *Significantly different from the model control groups at P < 0.05 (Dunnett’s test)