Table 2.
Prediction of response (pCR) by expression of miR-7 and miR-340 at baseline.
| [%] | NPV | Sensitivity | Specificity | PPV | Likelihood Ratio (p) |
|---|---|---|---|---|---|
|
miR-7 cutoff >0.55 |
96 | 86 | 54 | 21 | 4.3 (0.03) |
|
miR-340 cutoff <4.0 |
97 | 89 | 57 | 26 | 7.1 (<0.01) |
|
Combined profile* miR-7high/miR-340low |
96 | 71 | 86 | 42 | 9.8 (<0.01) |
p, two-sided level of significance for likelihood ratio assessed by Chi-Square test
NPV, negative predictive value; PPV, positive predictive value
*
prediction of pCR by a combination of high expression of miR-7 (>0.55) and low miR-340 (<4.0); patients showing expression outside the cutoff for either miR-7 or miR-340 were considered non-responders