Table 1.
Demographic, Drinking History Assessment, and Liver Injury Markers in Alcohol-Dependent Patients.
| Measures | Group 1 (Normal ALT, GR.1)
|
Group 2 (Elevated ALT, GR.2)
|
p-Value (GR.1 and GR. 2) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Males (34; 58.6%) | Females (24; 41.4%) | Within-gr.sex diff. p-value | Total (58; 50.4%) | Males (40; 70.2%) | Females (16; 29.8%) | Within-gr. sex diff. p-value | Total (56; 49.6%) | ||
| Age (years) | 37.6 ± 10.5 | 42.3 ± 10.6 | NS | 39.6 ± 10.7 | 43.0 ± 10.3 | 43.1 ± 10.3 | NS | 43.0 ± 10.2 | 0.080 |
| BMI (kg/m2) | 27.7 ± 4.2 | 25.7 ± 7.3 | NS | 26.9 ± 5.7 | 25.7 ± 3.8 | 26.3 ± 5.0 | NS | 25.9 ± 4.1 | NS |
| Drinking history | |||||||||
| TD90 | 957.2 ± 622.5 | 925.7 ± 735.1 | NS | 946.1 ± 656.9 | 1186.7 ± 528.5 | 950.3 ± 411.3 | NS | 1119.8 ± 505.9 | NS |
| HDD90 | 62.1 ± 26.9 | 62.7 ± 20.8 | NS | 62.3 ± 24.7 | 73.5 ± 20.7 | 76.8 ± 14.6 | NS | 74.5 ± 19.1 | 0.007 |
| AvgDD90 | 13.9 ± 7.9 | 13.0 ± 7.7 | NS | 13.6 ± 7.7 | 15.6 ± 5.9 | 12.1 ± 5.1 | NS | 14.6 ± 5.8 | NS |
| NDD90 | 67.4 ± 24.9 | 67.4 ± 21.0 | NS | 67.4 ± 23.4 | 76.7 ± 17.9 | 78.2 ± 13.6 | NS | 77.1 ± 16.7 | 0.017 |
| NNDD90 | 22.4 ± 24.9 | 22.5 ± 21.1 | NS | 22.4 ± 23.4 | 13.2 ± 17.9 | 11.8 ± 13.6 | NS | 12.8 ± 16.7 | 0.019 |
| Liver injury markers | |||||||||
| ALT (IU/l) | 28.9 ± 6.9 | 22.0 ± 8.3 | 0.001 | 26.0 ± 8.2 | 86.4 ± 35.3 | 111.9 ± 77.7 | NS | 93.6 ± 51.6 | NA |
| AST (IU/l) | 27.4 ± 16.2 | 28.8 ± 15.1 | NS | 28.0 ± 15.7 | 113.8 ± 79.5 | 181.4 ± 116.8 | 0.016 | 133.1 ± 95.7 | ≤0.001 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; TD90, total drinks past 90 days; HDD90, heavy drinking days past 90 days; AvgDD90, average drinks per drinking day past 90 days; NDD90, number of drinking days in past 90 days; NNDD90, number of nondrinking days in past 90 days; NS, not significant; NA, not applicable.
Age was significantly different only in males between GR.1 and GR.2 groups (p = 0.030). Males also showed significant differences in the BMI values between the GR.1 and GR.2 (p = 0.044). Markers of drinking history: HDD90, NNDD90, and NDD90 showed significant difference between the study arms. Data are presented as mean ± SD. Statistical significance was set at p ≤ 0.05; trend level of significance (noted in italics) at 0.05 ≤ p ≤ 0.1 (for presentation only).