(A), No significant differences were found in body weight loss ratios 24 hours after injury among the different groups. Only UFH225 UFH significantly worsened body weight loss above negative controls (No CCI) at 48 hours. 48 hours: *p < 0.05 vs. No CCI. (B), Neurological function was normal in negative controls (No CCI) at both timeframes. Compared to positive controls (CCI), UFH75 but not UFH225 improved GNT both 24 and 48 hours after injury. Compared to UFH225 UFH75 significantly improved GNT at 24 hours. 24 hours: **p < 0.01 vs. CCI + VEH, ◊p < 0.05 vs. CCI + 225 U/kg UFH, 48 hours, ##p < 0.01 vs. CCI + VEH.