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. Author manuscript; available in PMC: 2017 May 23.
Published in final edited form as: Annu Rev Pathol. 2016 Jan 13;11:21–45. doi: 10.1146/annurev-pathol-012615-044116

Figure 2.

Figure 2

Neocortical tau pathology in chronic traumatic encephalopathy. Tau immunoreactive profiles are distributed throughout the neocortex, although they typically show a preferential distribution toward the superficial neocortical layers and depths of sulci [a, 49-year-old male 12 months following single, severe traumatic brain injury (TBI)], with a distinctive and characteristic perivascular accentuation of immunoreactive neurons and glia, whether exposed to repetitive, mild TBI (b, 56-year-old male, former rugby player) or a single, moderate or severe TBI (c, 48-year-old male 3 years following a single, severe TBI). The accumulations of subpial thorn-shaped astrocytes may also be observed (d, 59-year-old male, former soccer player). All sections stained for phosphorylated tau using antibody CP-13 (courtesy of Dr. P. Davies).